Rutinol™

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Rutinol™

Smart sugar for biotech skin resilience

MOLECULAR INFORMATION

CAS No. 90-74-4

EC Number 202-014-4

INCI: Rutinose (biotech derived disaccharide)

Change source to: biocatalysis

PRODUCT DESCRIPTION

RUTINOL™ is a pure, water soluble, bioactive sugar with skin anti-aging effects. Produced by an environmentally friend biocatalysis process from citrus waste, Shreenika is the world’s only commercial manufacturer of rutinol™, which is traditionally complexed in plants and inaccessible to end users. RUTINOL™ increases skin elasticity and function by increasing collagen I production and by the inhibition of elastase, hyaluronidase, and collagenase. The high solubility of RUTINOL™ in water allows for easy formulation and high concentrations that support bioactivity. RUTINOL™ is especially bioactive in cellular models of aged and damaged cells, further supporting the anti-aging benefits of rutinol™ in restoring youthful skin appearance.

EFFICACY

INHIBITION OF ELASTASE IN VITRO

RUTINOL™ exhibits impressive in-vitro elastase inhibition. 50% inhibition at only 2.5 mM concentration.

RUTINOL™: IC50 = 2.5 mM; Equivalent to 0.8% concentration.

INHIBITION OF HYALURONIDASE IN VITRO

RUTINOL™ exhibits impressive in-vitro hyaluronidase inhibition at a broad use range. Over 50% inhibition at only .25 mM concentration.

RUTINOL™: IC50 = .25 mM; Equivalent to 0.08% concentration.

INHIBITION OF MMP-2 IN SKIN-AGING MODELS

RUTINOL™ further exhibits MMP inhibition in physiologically aged normal human dermal fibroblasts (NHDFs). Approximately 25% reduction in MMP-2 expression is observed at 10 mM concentration.

INCREASED COLLAGEN EXPRESSION IN SKIN CELLS

RUTINOL™ activates collagen production in normal human dermal fibroblasts (NHDFs). A 1 mM concentration appears to be highly efficacious, equating to a concentration of .32%.

CONCLUSION

RUTINOL™ is a multi-functional bioactive sugar that protects skin function and has potent anti-aging benefits. This rare sugar is posed to provide benefits to cosmetic products with a strong use potential at low concentrations that are extremely simple for formulators to incorporate.

TECHNICAL INFORMATION

PRODUCT SPECIFICATIONS

Heavy metals: < 10 ppm

Arsenic: < 2 ppm

Microbial count: < 100 CFU/g

Specified pathogens: Absent

Appearance: White, crystalline powder

Loss on drying: < 2%

Identity by IR-spectroscopy: corresponds to reference spectrum

Content: > 97%

PRESERVATION AND MICROBIOLOGY

As a pure crystalline product, RUTINOL™ doesn’t contain any preservative. RUTINOL™ is free of specified pathogens. The number of non-pathogenic microorganisms with less than 100 CFU per g of RUTINOL™ meets the CTFA microbiology guidelines.

SAFETY AND ECOLOGY

Standard and well-defined safety testing has been performed on RUTINOL™ which has proved the product to be safe for cosmetic use. The data available do not indicate any environmental risk. The manufacturing process is designed to meet the criteria for the assessment of safety, health and protection of people and of the environment set out in the Responsible Care Program.

PROCESSING AND DOSAGE

RUTINOL™ is soluble in both hot and cold water (+100 g/l at 20oC) and can be easily incorporated into cosmetic formulation either warm (< 70°C) or cold. RUTINOL™ is stable in the pH-range of 3-8. In formulations RUTINOL™ is compatible with UV filters and ethanol at concentrations of up to 50%. We recommend the addition of 0.1 up to 5%. Basic Guide Formulations are available upon request.

STORAGE AND SHELF LIFE

REMARK

Although these data and information have been prepared with the utmost possible care, we reserve the right to make changes due to product improvement and other considerations.

FORMULATION NOTES

Recommended use level: 0.1%–2%
Solubility: Highly water-soluble (100 g/L)
Stability: Stable across a broad pH and temperature range
Regulatory Status: Available for cosmetic use in the U.S., EU, and Asia (pending region-specific approvals)