Hesperetin

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History of Indigoidine

A naturally occurring blue pigment now called indigoidine, 135 years in the making, now accessible through biotechnology – and it’s history.

HISTORY

1890

Microbes that produce a blue pigment were discovered and investigated by a German Chemist, Claessen

1939

The blue pigment was isolated and investigated by another chemist and named indigoicine. The structure remained unknown still.

1965

The chemical structure of indigoidine was discovered after multiple years of study by Richard Kuhn. Making the pigment remained challenging since it is produced at low yields by natural microbes.

2002

The genes responsible for indigoidine biosynthesis were discovered, showing the natural production pathway of indigoidine for the first time

2012

The first genetically modified organism makes indigoicine.

2019

Multiple organisms have been engineered to make indigoine by academic labs. The product is nearly ready for a commercial application.

Now

Shreenika launches an industrial process for affordable indigoidine for the masses.

TECHNICAL INFORMATION

PRODUCT SPECIFICATIONS

Molecular Formula: C12H22O10

PRESERVATION AND MICROBIOLOGY

As a pure crystalline product, RUTINOSE doesn’t contain any preservative. RUTINOSE is free of specified pathogens. The number of non-pathogenic microorganisms with less than 100 CFU per g of RUTINOSE meets the CTFA microbiology guidelines.

REMARK

Although these data and information have been prepared with the utmost possible care, we reserve the right to make changes due to product improvement and other considerations.

FORMULATION NOTES

Although these data and information have been prepared with the utmost possible care, we reserve the right to make changes due to product improvement and other considerations.

Hesperetin

Cosmetics

Products

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A bio-based flavonoid, made sustainably

MOLECULAR INFORMATION

Molecular Formula: C16H14O6

Formula Weight: 302.28

Production Route: Biocatalysis

CAS No: 520-33-2

Source: Citrus

PRODUCT DESCRIPTION

HESPERETIN is a pure, bioderived, bioactive flavonoid. Produced by an environmentally friendly biocatalysis process, Shreenika is the world’s leading commercial manufacturer of hesperetin, which is traditionally complexed in plants and made by chemical processes that use acid and solvents. Our process uses unique technology to deliver best-in-class cost structure, sustainability, and high purity.

EFFICACY

Water solubility: Low

Oil solubility: Low

CONCLUSION

TECHNICAL INFORMATION

PRODUCT SPECIFICATIONS

Appearance: White, free flowing powder

Identity (by NMR) : Corresponds to reference spectrum

Loss on drying: < 1%

Heavy metals: < 5 ppm

Microbial count: < 100 CFU/g

Specified pathogens: Absent

SAFETY AND ECOLOGY

The data available do not indicate any environmental risk. The manufacturing process is designed to meet the criteria for the assessment of safety, health and protection of people and of the environment set out in the Responsible Care Program.

PRESERVATION AND MICROBIOLOGY

As a pure crystalline product, hesperetin doesn’t contain any preservative. Hesperetin is free of specified pathogens. The number of non-pathogenic microorganisms with less than 100 CFU per g of hesperetin meets the CTFA microbiology guidelines.

STORAGE AND SHELF LIFE

Hesperetin should be stored in the original sealed containers protected from light and humidity in a clean place at a temperature between 10 and 30°C. To avoid secondary microbial contamination, following opening, containers should be handled with special care. If stored under the recommended conditions, hesperetin remains stable for 2 years.

REMARK

Although these data and information have been prepared with the utmost possible care, we reserve the right to make changes due to product improvement and other considerations.